Nineteen of the Russian's 21 titles have been achieved on hardcourt
A revitalized Medvedev secured his initial trophy for nearly 30 months with a win over Corentin Moutet in the competition championship match.
The athlete, a former world number one, has endured a challenging year, managing just a single victory at the major tournaments and experiencing a difficult moment at the New York tournament.
Medvedev's varied form on the professional circuit - and issues with his serve in particular - caused him dropping out of the world's top 10 and finally separating with former trainer Cervara.
Now training with Thomas Johansson and Rohan Goetzke, the tennis star has gradually advanced in the past month - climaxing in a hard-fought competitive win over opponent Moutet.
This marks Medvedev's maiden championship following the Rome competition and initial on a hardcourt since spring of the previous year.
Victory also indicates the Russian has secured twenty-one championships at 21 various events.
"It's the first time I have attended a competition with my both daughters together, so to win a title is especially meaningful," stated ranked player the champion.
"This title is in honour of my younger daughter my daughter, because the maiden victory I won when my older daughter her name was born was for her."
Medvedev, the 2021 US Open champion, had been defeated in his past six title deciders, comprising in the German tournament in the past months.
His defensive strategy and frequent reactions on the playing surface had led observers to question if his ability to play at the top level was concluded.
But the athlete has made changes in recent weeks, striving to advance forward and compete assertively, reinforced by an better service.
Medvedev fought back from a deficit in the initial set against the challenging Moutet, securing four of the concluding five games to take the lead.
Both players exchanged break points in the middle set before the challenger, bidding for his maiden professional victory, took control to push for a final set.
He rescued four early chances in a close deciding set before Medvedev secured a break to that score to secure the win.
Suitably, he clinched the title with a shot at the net, with his opponent unable to handle a return after over two and a half hours.